Metabolic Maintenance

Resveratrol with Piperine

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Resveratrol is a powerful antioxidant that supports cardiovascular health, supports healthy platelet function and maintains healthy arachidonic acid metabolism. It may help to improve the metabolic profile of obese patients in a manner similar to caloric restriction and aid in their weight-loss journey by increasing stamina for exercise. Resveratrol also supports normal levels of both estrogen and testosterone production, thereby promoting fertility in men and women. Poor bioavailability and rapid metabolism of resveratrol have been the barriers to realizing its potential health benefits—until now. Based on recent scientific studies, we’ve combined resveratrol with piperine to significantly enhance absorption. Our formula contains the same resveratrol and piperine ratio that was demonstrated to slow the breakdown of resveratrol before reaching the site of absorption, thereby increasing dose efficiency and circulating resveratrol.

  • Offers improved bioavailability with the addition of piperine
  • Supports and protects cardiovascular health*
  • Provides potent antioxidant and anti-inflammatory properties*
  • Promotes healthy metabolism and exercise stamina for weight loss*

What is Resveratrol with Piperine?

Resveratrol is a naturally occurring phytoalexin produced by plants when under attack by pathogens, and can be found in grapes, red wine, berries, peanuts, and many other plants. Resveratrol has been shown to possess a multitude of health-promoting properties [1]. A few examples are supporting and protecting cardiovascular health, antioxidant and anti-inflammatory activities, and the promotion of healthy metabolism and exercise stamina for weight loss. Unfortunately, poor bioavailability and rapid metabolism of resveratrol have been barriers to realizing the potential health benefits—until now. 

Piperine has been shown to enhance the in vivo bioavailability of resveratrol via inhibition of glucuronidation, thereby slowing its metabolism, enhancing absorption, and making more resveratrol freely available in the circulation [1]. Our formula contains the same resveratrol and piperine ratio used in this breakthrough study [1]. Piperine is an alkaloid isolated from the plant Piper nigrum (black pepper) [2]. It’s what gives pepper its flavor and is also often added to turmeric or curcumin products to enhance the absorption of curcumin for its numerous health benefits.


How does Resveratrol with Piperine Work?

Resveratrol is a powerful antioxidant. Data suggest that resveratrol exerts its antioxidant action in different ways: it scavenges reactive oxygen species (ROS), increases the activity of enzymes that metabolize ROS, or decreases the activity of enzymes that play a role in ROS production [3]. 

It has been proposed that resveratrol is the nutrient that powers the “The French Paradox”, or why the French diet is high in saturated fat and red wine, yet french people seem to experience fewer cardiovascular pathologies. The oxidation of low-density lipoprotein (LDL) cholesterol is strongly associated with the risk of cardiovascular disease. Resveratrol prevents lipid peroxidation, inhibits the uptake of oxidized LDL, inhibits lipoxygenase activity, and is known to combat oxidative stress, and thereby supports overall cardiovascular health [2]. Moreover, resveratrol has been shown to protect cardiac tissue from cell death [3]. Its modulatory role in apoptosis and anti-inflammatory effects have also implicated resveratrol in the promotion of gut health and improved immune response [4]. You would have to drink A LOT of red wine to see a marked benefit from resveratrol, however, so it is much healthier (and produces fewer headaches) to take a supplement instead.

Resveratrol appears to activate enzymes that help muscles use oxygen more efficiently, leading to more endurance and stamina when exercising. This effect is hypothesized to be due to the fact that resveratrol increases the production of molecules called sirtuins, which may, in turn, increase the number of mitochondria, the machinery inside cells that turn oxygen and glucose into ATP energy [5]. On the cellular level, resveratrol also appears to increase the uptake of glucose by muscle cells, inhibiting the production of mature fat cells, and hindering fat storage [6]. This effect could also contribute to weight loss, as long as you are exercising.

In addition, resveratrol supports healthy human platelet function. It does so by lowering the levels of thiol proteins and hampers platelet aggregation and activation [3].


What is the Suggested Use for Resveratrol with Piperine?

  1. To support and protect your cardiovascular health (with improved bioavailability thanks to added piperine).
  2. Antioxidant and anti-inflammatory activities.
  3. To promote a healthy metabolism and weight loss. Resveratrol improves oxygen and glucose availability to increase exercise stamina. In addition, resveratrol supplementation in obese patients of both sexes has been shown to provide benefits that mimic caloric restriction by improving metabolic profiles and overall health parameters [7,8]. 
  4. To support healthy platelet function.


Source Materials: Resveratrol from Japanese knotweed (Polygonum cuspidatum) roots. Piperine from black pepper (Piper nigrum) fruit. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.


Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.

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